Schizophrenia susceptibility associated with interstitial deletions of chromosome 22q11.

Spectrum of clinical features associated with interstitial chromosome 22q11 deletions.

Chromosome 22q11 in a Xhosa schizophrenia population.

Chromosome 22q11 aberrations substantially increase the risk for developing schizophrenia. Although micro-deletions in this region have been extensively investigated in different populations across the world, little is known of their prevalence in African subjects with schizophrenia. We screened 110 African Xhosa-speaking participants with schizophrenia for the presence of micro-deletions. As f...

Background Velo-cardio-facial syndrome (VCFS) is associatedwith interstitial deletions of chromosome 22q11.About 30% of patientswithVCFS

Declaration of interest Funding fromthe PPPHealthcare Medical Trust, London,UK.Collection of probands in Bulgaria fundedby the Janssen Research Foundation and inthe UK by the Medical Research Council. Velo-cardio-facial syndrome (VCFS) is a genetic disorder associated with characteristic dysmorphology, cleft palate, cardiac anomalies and major psychiatric disorders, including schizophrenia (Shp...

Isolation of the subclavian artery associated with chromosome 22q11 deletion.

An interesting report on isolation of the subclavian artery appeared in the recent issue of this journal. The authors reported 3 patients with interruption of the aortic arch between the carotid arteries ('type B'), isolation of the subclavian artery, and deletion of the chromosome 22ql l . Isolation of the subclavian artery is a rare anomaly. Although the authors discussed only briefly the eti...

Truncus arteriosus communis associated with chromosome 22q11 deletion.

OBJECTIVES The purpose of this study was to clarify characteristics of truncus arteriosus communis associated with chromosome 22q11 deletion (del 22q11). BACKGROUND DiGeorge syndrome and conotruncal anomaly face syndrome are associated with del 22q11 (hemizygosity). In 30% of cases, truncus arteriosus communis is associated with the deletion. METHODS Fifteen consecutive patients with truncu...